MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]	1.83496	biological process	ceramide metabolic process
			signal transduction
		cellular component	cytoplasm
			soluble fraction
		molecular function	receptor signaling protein activity
Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]	2.96739	cellular component	nucleus
		molecular function	protein binding
Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]	2.57202	cellular component	integral to membrane
			membrane
Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]	4.14054	biological process	embryonic skeletal morphogenesis
			positive regulation of cell proliferation
		cellular component	intracellular
			nucleus
		molecular function	metal ion binding
			nucleic acid binding
			zinc ion binding
Protein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3 neighbouring gene protein). [Uniprot/SWISSPROT;Acc:Q96C90]	2.75351	cellular component	cytoplasm
		molecular function	protein phosphatase inhibitor activity
Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]	2.2866	biological process	positive regulation of I-kappaB kinase/NF-kappaB cascade
			protein amino acid dephosphorylation
		cellular component	membrane fraction
			neuron projection
			protein serine/threonine phosphatase complex
			voltage-gated calcium channel complex
		molecular function	catalytic activity
			hydrolase activity
			magnesium ion binding
			manganese ion binding
			protein binding
			protein C-terminus binding
			protein phosphatase type 2C activity
			protein serine/threonine phosphatase activity
			signal transducer activity
Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Uniprot/SWISSPROT;Acc:Q8TE77]	2.95579	biological process	dephosphorylation
			protein amino acid dephosphorylation
		cellular component	cytoplasm
			cytoskeleton
			nucleus
		molecular function	hydrolase activity
			phosphoric monoester hydrolase activity
			protein tyrosine phosphatase activity
			protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase domain containing 1 protein isoform 2 [RefSeq_peptide;Acc:NP_818931]	1.22528	biological process	dephosphorylation
			protein amino acid dephosphorylation
		molecular function	hydrolase activity
			phosphoric monoester hydrolase activity
			protein tyrosine phosphatase activity
			protein tyrosine/serine/threonine phosphatase activity
Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	1.61987	biological process	activation of MAPKK activity
			anatomical structure morphogenesis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.