MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 468 to 517 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
1.43088	isopentenyl-diphosphate delta-isomerase activity	Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	molecular function
	isoprenoid biosynthetic process		biological process
	magnesium ion binding		molecular function
	peroxisome		cellular component
1.43351	carboxypeptidase A activity	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]	molecular function
	carboxypeptidase activity
	metal ion binding
	metallopeptidase activity
	proteolysis		biological process
	vacuolar protein catabolic process
	zinc ion binding		molecular function
1.44004	extracellular space	Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]	cellular component
	receptor binding		molecular function
	signal transduction		biological process
	soluble fraction		cellular component
1.48363	ATP binding	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291]	molecular function
	cell cycle		biological process
	cell division
	magnesium ion binding		molecular function
	mitosis		biological process
	nucleotide binding		molecular function
	nucleus		cellular component
	protein amino acid phosphorylation		biological process
	protein binding		molecular function
	protein kinase activity
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	regulation of progression through cell cycle		biological process
	transferase activity		molecular function
1.48389	ATP binding	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]
	ATP synthesis coupled proton transport		biological process
	DNA binding		molecular function
	hydrogen ion transporting ATP synthase activity, rotational mechanism
	hydrogen ion transporting ATPase activity, rotational mechanism
	intracellular		cellular component
	intracellular protein transport across a membrane		biological process
	metal ion binding		molecular function
	mRNA transport		biological process
	nuclear pore		cellular component
	nucleus
	protein binding		molecular function
	protein transport		biological process
	proton-transporting two-sector ATPase complex		cellular component
	transporter activity		molecular function
	zinc ion binding
1.49271	cell cycle	Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]	biological process
	cellular_component		cellular component
	DNA repair		biological process
	molecular_function		molecular function
	protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.