MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Class	Ratio	Regulation	description	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 2667 in total

Class  : molecular function

Ratio	Regulation	description	Gene Ontology
1.44789	up	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Uniprot/SWISSPROT;Acc:Q16633]	transcription coactivator activity
1.45148		Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]	DNA binding
			protein binding
1.45314		NULL	DNA binding
1.45624		Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]
			protein dimerization activity
			sequence-specific DNA binding
			transcription coactivator activity
			transcription factor activity
1.45635		Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]	protein binding
1.4628		Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Uniprot/SWISSPROT;Acc:Q9NQS3]
			protein homodimerization activity
			receptor activity
1.48363	down	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291]	ATP binding
			magnesium ion binding
			nucleotide binding
			protein binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
1.48389		Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]	ATP binding
			DNA binding
			hydrogen ion transporting ATP synthase activity, rotational mechanism
			hydrogen ion transporting ATPase activity, rotational mechanism
			metal ion binding
			protein binding
			transporter activity
			zinc ion binding
1.49264	up	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]	heme binding
			iron ion binding
			metal ion binding
			monooxygenase activity
			oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
1.49271	down	Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]	molecular_function
			protein binding
1.49444	up	Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	ligase activity
			small conjugating protein ligase activity
			ubiquitin-protein ligase activity
1.49558	down	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	cytokine activity
			growth factor activity
			protein binding
			transforming growth factor beta receptor binding
1.49923		Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	guanyl-nucleotide exchange factor activity
			protein binding
1.50206	up	LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]	sequence-specific DNA binding
			transcription factor activity
1.50284	down	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	protein binding
			protein transporter activity
1.50715		F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Uniprot/SWISSPROT;Acc:Q969U6]	protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.