MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Class	Ratio	Gene Ontology	Regulation	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2019 to 2068 of 2667 in total

description	Class	Ratio	Gene Ontology	Regulation
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	molecular function	1.65835	translation elongation factor activity	down
			tRNA binding
Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	biological process	1.21657	cell cycle	up
			cytokinesis
			positive regulation of exocytosis
			regulation of exocytosis
			small GTPase mediated signal transduction
			synaptic vesicle targeting
	cellular component		plasma membrane
			synaptic vesicle
			synaptosome
	molecular function		GTP binding
			GTPase activity
			nucleotide binding
			protein binding
			structural molecule activity
			syntaxin binding
Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]	biological process	6.50865	protein amino acid phosphorylation
	molecular function		ATP binding
			magnesium ion binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	biological process	1.22178	protein amino acid phosphorylation
	cellular component		cytoplasm
			cytosol
			nucleus
	molecular function		ATP binding
			heme binding
			nucleotide binding
			protein binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
			transition metal ion binding
Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	biological process	4.14557	protein amino acid phosphorylation	down
	cellular component		nucleus
	molecular function		ATP binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			transferase activity
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	biological process	2.31699	protein amino acid dephosphorylation
	cellular component		cytoplasm
			protein phosphatase type 2A complex
	molecular function		hydrolase activity
			iron ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.