MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Ratio	Class	Gene Ontology	Gene	Accession	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 2019 to 2068 of 2667 in total

description	Regulation	Ratio	Class	Gene Ontology
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	down	1.65835	molecular function	translation elongation factor activity
				tRNA binding
Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	up	1.21657	biological process	cell cycle
				cytokinesis
				positive regulation of exocytosis
				regulation of exocytosis
				small GTPase mediated signal transduction
				synaptic vesicle targeting
			cellular component	plasma membrane
				synaptic vesicle
				synaptosome
			molecular function	GTP binding
				GTPase activity
				nucleotide binding
				protein binding
				structural molecule activity
				syntaxin binding
Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]		6.50865	biological process	protein amino acid phosphorylation
			molecular function	ATP binding
				magnesium ion binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]		1.22178	biological process	protein amino acid phosphorylation
			cellular component	cytoplasm
				cytosol
				nucleus
			molecular function	ATP binding
				heme binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
				transition metal ion binding
Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	down	4.14557	biological process	protein amino acid phosphorylation
			cellular component	nucleus
			molecular function	ATP binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				transferase activity
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]		2.31699	biological process	protein amino acid dephosphorylation
			cellular component	cytoplasm
				protein phosphatase type 2A complex
			molecular function	hydrolase activity
				iron ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.