MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	Ratio	Gene Ontology	description	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1851 to 1900 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.59177	protein binding	Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]	molecular function
1.59188	DNA binding	Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Uniprot/SWISSPROT;Acc:Q8TF68]
	intracellular		cellular component
	metal ion binding		molecular function
	nucleic acid binding
	nucleus		cellular component
	regulation of transcription, DNA-dependent		biological process
	transcription
	zinc ion binding		molecular function
1.59819	calcium ion binding	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]
	detection of stimulus during sensory perception		biological process
	hydrolase activity		molecular function
	iron ion binding
	manganese ion binding
	phosphoprotein phosphatase activity
	protein amino acid dephosphorylation		biological process
	protein serine/threonine phosphatase activity		molecular function
	response to stimulus		biological process
	visual perception
1.60668	calcium channel activity	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]	molecular function
	calcium ion binding
	calcium ion homeostasis		biological process
	calcium ion transport
	calmodulin binding		molecular function
	identical protein binding
	integral to membrane		cellular component
	ion channel activity		molecular function
	ion transport		biological process
	membrane		cellular component
	osmosensory signaling pathway		biological process
	plasma membrane		cellular component
	regulation of cell volume		biological process
	response to mechanical stimulus
1.61673	ATP binding	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]	molecular function
	calcium ion binding
	calmodulin binding
	cytoplasm		cellular component
	nucleotide binding		molecular function
	nucleus		cellular component
	protein amino acid phosphorylation		biological process
	protein kinase activity		molecular function
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	transferase activity
1.61987	activation of MAPKK activity	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	biological process
	anatomical structure morphogenesis
	apoptosis
	blood coagulation
	caspase activation
	cell motility

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.