MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 201 to 250 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.24359	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]	cellular component	cell junction
			cytoplasmic vesicle
			membrane
			synapse
		molecular function	calcium ion binding
			lipid binding
1.24361	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	biological process	metabolic process
			protein amino acid glycosylation
		cellular component	endoplasmic reticulum
			ER-Golgi intermediate compartment
			Golgi apparatus
			integral to membrane
			membrane
			membrane fraction
		molecular function	calcium ion binding
			hydrolase activity, acting on glycosyl bonds
			mannosidase activity
			mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
1.24964	Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Uniprot/SWISSPROT;Acc:Q8NHH9]	biological process	immune response
		cellular component	integral to membrane
			membrane
		molecular function	GTP binding
			GTPase activity
			nucleotide binding
			protein binding
1.25113	Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). [Uniprot/SWISSPROT;Acc:Q15072]	biological process	regulation of transcription, DNA-dependent
		cellular component	intracellular
			nucleus
		molecular function	DNA binding
			heparin binding
			metal ion binding
			nucleic acid binding
			zinc ion binding
1.25205	Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]	biological process	nuclear mRNA splicing, via spliceosome
			RNA splicing
			SRP-dependent cotranslational protein targeting to membrane
		cellular component	membrane
			nucleus
			spliceosome
		molecular function	7S RNA binding
			GTP binding
			RNA binding
1.27461	Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	biological process	anatomical structure morphogenesis
			G-protein coupled receptor protein signaling pathway
			multicellular organismal development
			regulation of transcription, DNA-dependent
			thyroid gland development
		cellular component	integral to membrane
			nucleus
		molecular function	DNA binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.