MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1969 to 2018 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.66123	KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]	cellular component	membrane
		molecular function	muscarinic acetylcholine receptor activity
			nucleic acid binding
1.66679	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	biological process	protein amino acid ADP-ribosylation
		cellular component	nucleus
		molecular function	metal ion binding
			NAD+ ADP-ribosyltransferase activity
			nucleic acid binding
			protein binding
			transferase activity, transferring glycosyl groups
			zinc ion binding
1.69345	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]	biological process	regulation of transcription
			regulation of transcription, DNA-dependent
		cellular component	nucleus
		molecular function	DNA binding
			RNA polymerase II transcription factor activity
			transcription factor activity
1.69856	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	biological process	neuromuscular synaptic transmission
			protein amino acid phosphorylation
		cellular component	cytoplasm
		molecular function	ATP binding
			calmodulin binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
1.73291	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	biological process	potassium ion transport
		cellular component	membrane
			voltage-gated potassium channel complex
		molecular function	protein binding
			voltage-gated potassium channel activity
1.75026	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	biological process	axon ensheathment
			calcium-independent cell-cell adhesion
			cell adhesion
			spermatogenesis
		cellular component	cell junction
			integral to membrane
			membrane
			tight junction
		molecular function	identical protein binding
			structural molecule activity
1.78439	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	biological process	chromatin assembly or disassembly
			chromatin modification
			chromosome organization and biogenesis (sensu Eukaryota)
			intracellular signaling cascade
			regulation of transcription from RNA polymerase II promoter
			transcription
		cellular component	chromatin
			nucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.