MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Ratio	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1951 to 2000 of 2667 in total

description	Regulation	Ratio	Gene Ontology	Class
RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	down	5.61927	protein binding	molecular function
			transport	biological process
			zinc ion binding	molecular function
RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]	up	3.35536	calmodulin binding
			nucleolus	cellular component
			nucleus
			regulation of transcription, DNA-dependent	biological process
			transcription
RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]		2.86965	ATP binding	molecular function
			chromosome	cellular component
			DNA binding	molecular function
			DNA topoisomerase (ATP-hydrolyzing) activity
			DNA topological change	biological process
			nucleic acid binding	molecular function
			nucleotide binding
			nucleus	cellular component
			RNA binding	molecular function
RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]		1.42264	cytoplasm	cellular component
			homoiothermy	biological process
			ice binding	molecular function
			intracellular	cellular component
			metal ion binding	molecular function
			mRNA processing	biological process
			nucleic acid binding	molecular function
			nucleotide binding
			nucleus	cellular component
			response to freezing	biological process
			ribosome	cellular component
			RNA binding	molecular function
			RNA splicing	biological process
			structural constituent of ribosome	molecular function
			translation	biological process
			type I hypersensitivity
			zinc ion binding	molecular function
S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]		1.16823	cell proliferation	biological process
			G1/S transition of mitotic cell cycle
			protein binding	molecular function
			regulation of progression through cell cycle	biological process
			ubiquitin cycle
SAC3 domain containing 1 [RefSeq_peptide;Acc:NP_037431]		2.75048	centrosome	cellular component
			centrosome duplication	biological process
			spindle	cellular component
			spindle assembly	biological process
Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]		4.04651	condensed nuclear chromosome	cellular component
			endosome
			integral to membrane
			membrane
			microtubule binding	molecular function
			mitotic spindle organization and biogenesis	biological process
			nuclear chromosome, telomeric region	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.