MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1950 to 1999 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.69364	up	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	biological process	retinoic acid metabolic process
				retinoic acid receptor signaling pathway
			cellular component	endoplasmic reticulum
				membrane
				microsome
			molecular function	heme binding
				iron ion binding
				metal ion binding
				monooxygenase activity
				oxygen binding
				retinoic acid 4-hydroxylase activity
2.7017		Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]	biological process	chromosome organization and biogenesis (sensu Eukaryota)
				G-protein signaling, adenylate cyclase inhibiting pathway
				nucleosome assembly
				synaptic transmission
			cellular component	chromosome
				chromosome, pericentric region
				extracellular region
				nucleosome
				nucleus
				soluble fraction
			molecular function	DNA binding
				G-protein-coupled receptor binding
				hormone activity
				neuropeptide hormone activity
2.70687		Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	biological process	homoiothermy
				response to freezing
				translation
			cellular component	intracellular
				ribosome
			molecular function	calcium ion binding
				ice binding
				structural constituent of ribosome
2.72371		Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]	biological process	cell communication
			cellular component	Cajal body
				cellular_component
				chromatin
				chromocenter
				nucleus
			molecular function	protein binding
2.75048		SAC3 domain containing 1 [RefSeq_peptide;Acc:NP_037431]	biological process	centrosome duplication
				spindle assembly
			cellular component	centrosome
				spindle
2.75351		Protein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3 neighbouring gene protein). [Uniprot/SWISSPROT;Acc:Q96C90]		cytoplasm
			molecular function	protein phosphatase inhibitor activity
2.75593	down	ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	biological process	protein modification process
2.79087		leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]		defense response
			cellular component	integral to membrane
				membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.