MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1940 to 1989 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]	2.12709	down	molecular function	identical protein binding
				ribonuclease activity
				ribonuclease P activity
				RNA binding
RIM-binding protein 2 (RIM-BP2). [Uniprot/SWISSPROT;Acc:O15034]	2.27115		cellular component	cell junction
				membrane
				synapse
RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	5.61927		biological process	transport
			cellular component	integral to membrane
				membrane
			molecular function	metal ion binding
				nucleoside transporter activity
				protein binding
				zinc ion binding
RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]	3.35536	up	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleolus
				nucleus
			molecular function	calmodulin binding
RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]	2.86965		biological process	DNA topological change
			cellular component	chromosome
				nucleus
			molecular function	ATP binding
				DNA binding
				DNA topoisomerase (ATP-hydrolyzing) activity
				nucleic acid binding
				nucleotide binding
				RNA binding
RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]	1.42264		biological process	homoiothermy
				mRNA processing
				response to freezing
				RNA splicing
				translation
				type I hypersensitivity
			cellular component	cytoplasm
				intracellular
				nucleus
				ribosome
			molecular function	ice binding
				metal ion binding
				nucleic acid binding
				nucleotide binding
				RNA binding
				structural constituent of ribosome
				zinc ion binding
S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]	1.16823		biological process	cell proliferation
				G1/S transition of mitotic cell cycle
				regulation of progression through cell cycle
				ubiquitin cycle
			molecular function	protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.