MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1940 to 1989 of 2667 in total

Regulation  : up

Ratio	Class	description	Gene Ontology
2.65068	biological process	NULL	complement activation
			proteolysis
	cellular component		extracellular region
	molecular function		calcium ion binding
			serine-type endopeptidase activity
2.69364	biological process	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	anterior/posterior pattern formation
			central nervous system development
			electron transport
			metabolic process
			neural crest cell development
			retinoic acid metabolic process
			retinoic acid receptor signaling pathway
	cellular component		endoplasmic reticulum
			membrane
			microsome
	molecular function		heme binding
			iron ion binding
			metal ion binding
			monooxygenase activity
			oxygen binding
			retinoic acid 4-hydroxylase activity
2.7017	biological process	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]	chromosome organization and biogenesis (sensu Eukaryota)
			G-protein signaling, adenylate cyclase inhibiting pathway
			nucleosome assembly
			synaptic transmission
	cellular component		chromosome
			chromosome, pericentric region
			extracellular region
			nucleosome
			nucleus
			soluble fraction
	molecular function		DNA binding
			G-protein-coupled receptor binding
			hormone activity
			neuropeptide hormone activity
2.70687	biological process	Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	homoiothermy
			response to freezing
			translation
	cellular component		intracellular
			ribosome
	molecular function		calcium ion binding
			ice binding
			structural constituent of ribosome
2.72371	biological process	Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]	cell communication
	cellular component		Cajal body
			cellular_component
			chromatin
			chromocenter
			nucleus
	molecular function		protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.