MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1890 to 1939 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.45875	up	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]	molecular function	peptidase activity
				zinc ion binding
2.48474		BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). [Uniprot/SWISSPROT;Acc:O15155]	biological process	ER to Golgi vesicle-mediated transport
				protein transport
			cellular component	endoplasmic reticulum
				Golgi apparatus
				Golgi membrane
				integral to membrane
				membrane
			molecular function	protein binding
2.49031		Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	biological process	nervous system development
				protein transport
			molecular function	protein binding
2.4954		OMA1 homolog, zinc metallopeptidase [RefSeq_peptide;Acc:NP_660286]	biological process	proteolysis
			cellular component	membrane
			molecular function	metalloendopeptidase activity
				metallopeptidase activity
				zinc ion binding
2.51088	down	Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]	biological process	lipid metabolic process
				transport
			molecular function	binding
				structural constituent of cell wall
				transporter activity
2.54508	up	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]	biological process	cell adhesion
				cell-cell adhesion
				intercellular junction maintenance
				synaptogenesis
			cellular component	integral to membrane
				membrane
				postsynaptic membrane
				synapse
			molecular function	cholinesterase activity
				neurexin binding
2.57202		Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]	cellular component	integral to membrane
				membrane
2.58329	down	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	biological process	cell differentiation
				multicellular organismal development
				nervous system development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	calcium ion binding
				metal ion binding
				transcription factor activity
				zinc ion binding
2.61135		28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]	biological process	DNA damage response, detection of DNA damage
				peptide biosynthetic process
			cellular component	mitochondrial small ribosomal subunit
				mitochondrion
				ribonucleoprotein complex

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.