MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1851 to 1900 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.59177	Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]	molecular function	protein binding
1.59188	Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Uniprot/SWISSPROT;Acc:Q8TF68]	biological process	regulation of transcription, DNA-dependent
			transcription
		cellular component	intracellular
			nucleus
		molecular function	DNA binding
			metal ion binding
			nucleic acid binding
			zinc ion binding
1.59819	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]	biological process	detection of stimulus during sensory perception
			protein amino acid dephosphorylation
			response to stimulus
			visual perception
		molecular function	calcium ion binding
			hydrolase activity
			iron ion binding
			manganese ion binding
			phosphoprotein phosphatase activity
			protein serine/threonine phosphatase activity
1.60668	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]	biological process	calcium ion homeostasis
			calcium ion transport
			ion transport
			osmosensory signaling pathway
			regulation of cell volume
			response to mechanical stimulus
		cellular component	integral to membrane
			membrane
			plasma membrane
		molecular function	calcium channel activity
			calcium ion binding
			calmodulin binding
			identical protein binding
			ion channel activity
1.61673	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]	biological process	protein amino acid phosphorylation
		cellular component	cytoplasm
			nucleus
		molecular function	ATP binding
			calcium ion binding
			calmodulin binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
1.61987	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	biological process	activation of MAPKK activity
			anatomical structure morphogenesis
			apoptosis
			blood coagulation
			caspase activation
			cell motility

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.