MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1851 to 1900 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]	3.21581	molecular function	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
			endonuclease activity
			hydrolase activity
			nucleotide binding
			protein binding
Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	1.2734	biological process	cell adhesion
			neurotransmitter secretion
			synaptic transmission
			synaptogenesis
		cellular component	integral to membrane
			membrane
		molecular function	calcium channel regulator activity
			calcium ion binding
			protein binding
Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]	2.54508	biological process	cell adhesion
			cell-cell adhesion
			intercellular junction maintenance
			synaptogenesis
		cellular component	integral to membrane
			membrane
			postsynaptic membrane
			synapse
		molecular function	cholinesterase activity
			neurexin binding
Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]	1.10889	biological process	regulation of transcription, DNA-dependent
			transcription
		cellular component	cytoplasm
			nucleus
		molecular function	protein dimerization activity
			sequence-specific DNA binding
			transcription factor activity
Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105). [Uniprot/SWISSPROT;Acc:Q9NQ35]	3.32356	biological process	proteolysis
		molecular function	aspartic-type endopeptidase activity
			sugar binding
Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Uniprot/SWISSPROT;Acc:Q9GZY0]	1.19207	biological process	mRNA export from nucleus
			multicellular organismal development
			transport
		cellular component	cytoplasm
			intracellular
			nuclear RNA export factor complex
			nucleus
		molecular function	nucleotide binding
			protein binding
			RNA binding
NULL	1.18711		protein binding
	1.37553	biological process	protein folding
		molecular function	peptidyl-prolyl cis-trans isomerase activity
	1.40093		protein binding
	1.45314		DNA binding
	2.65068	biological process	complement activation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.