MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1840 to 1889 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.31699	down	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	biological process	protein amino acid dephosphorylation
			cellular component	cytoplasm
				protein phosphatase type 2A complex
			molecular function	hydrolase activity
				iron ion binding
				manganese ion binding
				metal ion binding
				phosphoprotein phosphatase activity
				protein binding
				protein phosphatase type 2A activity
2.33107		F-box only protein 15. [Uniprot/SWISSPROT;Acc:Q8NCQ5]	biological process	ubiquitin cycle
			cellular component	SCF ubiquitin ligase complex
			molecular function	protein binding
2.37788	up	Coiled-coil domain-containing protein 83. [Uniprot/SWISSPROT;Acc:Q8IWF9]	cellular component	viral capsid
			molecular function	structural molecule activity
2.43098		Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2). [Uniprot/SWISSPROT;Acc:Q9H1P3]	biological process	lipid transport
				steroid metabolic process
2.44552	down	Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]		G-protein coupled receptor protein signaling pathway
				protein amino acid ADP-ribosylation
				signal transduction
			cellular component	heterotrimeric G-protein complex
				plasma membrane
			molecular function	GTP binding
				GTPase activity
				guanyl nucleotide binding
				nucleotide binding
				signal transducer activity
2.45383		40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]	biological process	translation
			cellular component	cytosolic small ribosomal subunit (sensu Eukaryota)
				intracellular
				ribosome
				small ribosomal subunit
			molecular function	RNA binding
				structural constituent of ribosome
2.45764	up	zinc transporter like 2 [RefSeq_peptide;Acc:NP_598003]	biological process	cation transport
				zinc ion transport
			cellular component	cytoplasmic membrane-bound vesicle
				Golgi apparatus
				membrane
			molecular function	cation transporter activity
				protein binding
				zinc ion transporter activity
2.45875		ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]	biological process	proteolysis
			cellular component	extracellular matrix
				intracellular
				proteinaceous extracellular matrix
			molecular function	metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				nucleic acid binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.