MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1801 to 1850 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	1.61987	up	cellular component	integral to plasma membrane
				neuromuscular junction
				plasma membrane
				postsynaptic membrane
			molecular function	G-protein coupled receptor activity
				purinergic nucleotide receptor activity, G-protein coupled
				receptor activity
				receptor binding
				rhodopsin-like receptor activity
				thrombin receptor activity
Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Uniprot/SWISSPROT;Acc:P07947]	2.20843		biological process	glucose transport
				intracellular signaling cascade
				protein amino acid autophosphorylation
				protein amino acid phosphorylation
				protein modification process
			cellular component	cytoplasm
				membrane fraction
			molecular function	ATP binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	1.81557	down	biological process	homoiothermy
				response to freezing
			cellular component	nucleus
			molecular function	ATP binding
				DNA binding
				helicase activity
				hydrolase activity
				ice binding
				nucleic acid binding
				nucleotide binding
pyrin and HIN domain family, member 1 alpha 1 isoform [RefSeq_peptide;Acc:NP_689714]	1.08658			protein binding
Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	4.71132		biological process	glycolysis
				response to other organism
			cellular component	cellular_component
			molecular function	magnesium ion binding
				potassium ion binding
				pyruvate kinase activity
				transferase activity
rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]	5.53059	up	biological process	intracellular protein transport
				nucleocytoplasmic transport
				protein transport
				signal transduction
				small GTPase mediated signal transduction
			cellular component	intracellular
			molecular function	GTP binding
				GTPase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.