MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	description	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1790 to 1839 of 2667 in total

Ratio	description	Regulation	Class	Gene Ontology
2.20843	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Uniprot/SWISSPROT;Acc:P07947]	up	molecular function	protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
2.25955	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]	down	biological process	threonyl-tRNA aminoacylation
				translation
				tRNA aminoacylation for protein translation
			cellular component	cytoplasm
				mitochondrion
			molecular function	aminoacyl-tRNA ligase activity
				ATP binding
				ligase activity
				nucleotide binding
				threonine-tRNA ligase activity
2.27115	RIM-binding protein 2 (RIM-BP2). [Uniprot/SWISSPROT;Acc:O15034]		cellular component	cell junction
				membrane
				synapse
2.2866	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]	up	biological process	positive regulation of I-kappaB kinase/NF-kappaB cascade
				protein amino acid dephosphorylation
			cellular component	membrane fraction
				neuron projection
				protein serine/threonine phosphatase complex
				voltage-gated calcium channel complex
			molecular function	catalytic activity
				hydrolase activity
				magnesium ion binding
				manganese ion binding
				protein binding
				protein C-terminus binding
				protein phosphatase type 2C activity
				protein serine/threonine phosphatase activity
				signal transducer activity
2.29381	Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]		biological process	cell death
				nuclear organization and biogenesis
				visual perception
			cellular component	cytoplasm
				intracellular
				nucleus
			molecular function	chromatin binding
				protein binding
				zinc ion binding
2.2939	Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]		biological process	organelle organization and biogenesis
				pigmentation
			cellular component	cytoplasm
2.31039	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]		biological process	maintenance of protein localization in nucleus
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.