MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1740 to 1789 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.42264	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]	molecular function	RNA binding
			structural constituent of ribosome
			zinc ion binding
1.44789	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Uniprot/SWISSPROT;Acc:Q16633]	biological process	humoral immune response
			regulation of transcription, DNA-dependent
			transcription
			transcription from RNA polymerase II promoter
		cellular component	nucleus
		molecular function	DNA binding
			protein binding
			transcription coactivator activity
1.45148	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]	biological process	Golgi organization and biogenesis
			regulation of transcription, DNA-dependent
			vesicle-mediated transport
		cellular component	ER-Golgi intermediate compartment
			Golgi apparatus
			Golgi membrane
			Golgi stack
			integral to membrane
			membrane
			nucleus
		molecular function	DNA binding
			protein binding
1.45314	NULL		DNA binding
1.45624	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]	biological process	circulation
			hemostasis
			multicellular organismal development
			regulation of transcription
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
		cellular component	nucleus
		molecular function	DNA binding
			protein dimerization activity
			sequence-specific DNA binding
			transcription coactivator activity
			transcription factor activity
1.45635	Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]	biological process	cell cycle
			cell division
			mitosis
			mitotic G2 checkpoint
			positive regulation of transcription
			regulation of cyclin-dependent protein kinase activity
			regulation of progression through cell cycle
		cellular component	cytoplasm
			female pronucleus
			male pronucleus
			nucleus
		molecular function	protein binding
1.4628	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Uniprot/SWISSPROT;Acc:Q9NQS3]	biological process	cell adhesion
			homophilic cell adhesion

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.