MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	Gene Ontology	description	Class	Gene	Accession	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 1701 to 1750 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
1.96673	up	microsome	Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]	cellular component
		peptidase activity		molecular function
		proteolysis		biological process
		serine-type peptidase activity		molecular function
		signal peptide processing		biological process
1.98137	down	DNA binding	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]	molecular function
		ligand-dependent nuclear receptor activity
		metal ion binding
		nucleus		cellular component
		protein binding		molecular function
		regulation of transcription, DNA-dependent		biological process
		sequence-specific DNA binding		molecular function
		signal transduction		biological process
		steroid hormone receptor activity		molecular function
		thyroid hormone receptor activity
		transcription		biological process
		transcription factor activity		molecular function
		zinc ion binding
1.98149	up	anti-apoptosis	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]	biological process
		B cell differentiation
		B cell proliferation
		CD40 receptor binding		molecular function
		cytokine activity
		extracellular space		cellular component
		immune response		biological process
		inflammatory response
		integral to membrane		cellular component
		integral to plasma membrane
		isotype switching		biological process
		leukocyte adhesion
		membrane		cellular component
		platelet activation		biological process
		regulation of immunoglobulin secretion
		soluble fraction		cellular component
		tumor necrosis factor receptor binding		molecular function
2.07532		cell junction	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]	cellular component
		cytoplasm
		cytoskeletal anchoring		biological process
		dendrite		cellular component
		intracellular
		membrane fraction
		postsynaptic membrane
		protein binding		molecular function
		synapse		cellular component
2.08208	down	extracellular region	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]
		hyaluronan metabolic process		biological process
		serine-type endopeptidase inhibitor activity		molecular function
2.10428	up	cellular process	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]	biological process
		DNA binding		molecular function
		leading edge cell differentiation		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.