MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1701 to 1750 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]	2.57202	up	cellular component	membrane
Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	6.3909	down	biological process	apoptosis
				intracellular signaling cascade
				negative regulation of cell growth
				regulation of transcription, DNA-dependent
				response to stress
				transcription
			cellular component	cytoplasm
				nucleus
			molecular function	metal ion binding
				protein binding
				zinc ion binding
Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	1.13541		biological process	blood coagulation
				cell adhesion
				regulation of growth
			cellular component	extracellular region
				membrane
			molecular function	calcium ion binding
				protein binding
				structural molecule activity
				transmembrane receptor activity
Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]	4.14054	up	biological process	embryonic skeletal morphogenesis
				positive regulation of cell proliferation
			cellular component	intracellular
				nucleus
			molecular function	metal ion binding
				nucleic acid binding
				zinc ion binding
Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]	3.71868	down	biological process	translation
			cellular component	nucleus
			molecular function	protein binding
Protein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3 neighbouring gene protein). [Uniprot/SWISSPROT;Acc:Q96C90]	2.75351	up	cellular component	cytoplasm
			molecular function	protein phosphatase inhibitor activity
protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	1.72656	down	biological process	ER overload response
				response to hydrogen peroxide
				response to oxidative stress
			cellular component	protein phosphatase type 1 complex
			molecular function	protein serine/threonine phosphatase activity
Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]	2.2866	up	biological process	positive regulation of I-kappaB kinase/NF-kappaB cascade
				protein amino acid dephosphorylation
			cellular component	membrane fraction
				neuron projection
				protein serine/threonine phosphatase complex
				voltage-gated calcium channel complex
			molecular function	catalytic activity
				hydrolase activity
				magnesium ion binding
				manganese ion binding
				protein binding
				protein C-terminus binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.