MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1701 to 1750 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	2.2939	cellular component	cytoplasm
Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]	1.30407	biological process	axonogenesis
			multicellular organismal development
			regulation of transcription, DNA-dependent
			transcription from RNA polymerase II promoter
		cellular component	nucleus
		molecular function	RNA polymerase II transcription factor activity
			sequence-specific DNA binding
			transcription factor activity
Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]	3.70292	biological process	anatomical structure development
			embryonic skeletal morphogenesis
			homoiothermy
			inner ear morphogenesis
			multicellular organismal development
			myoblast migration
			positive regulation of transcription
			regulation of transcription, DNA-dependent
			response to freezing
			striated muscle development
			thymus development
		cellular component	nucleus
		molecular function	ice binding
			sequence-specific DNA binding
			transcription factor activity
HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]	1.22047	biological process	mitosis
		cellular component	nucleus
Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]	1.19496	biological process	carbohydrate metabolic process
			glutathione metabolic process
			glyoxylate cycle
			isocitrate metabolic process
			metabolic process
			response to oxidative stress
			tricarboxylic acid cycle
		cellular component	cytoplasm
			cytosol
			peroxisome
		molecular function	isocitrate dehydrogenase (NADP+) activity
			magnesium ion binding
			manganese ion binding
			oxidoreductase activity
			oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]	1.21698	biological process	electron transport
			metabolic process
		molecular function	oxidoreductase activity
			protein binding
KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]	1.66123	biological process	G-protein coupled receptor protein signaling pathway
			regulation of transcription, DNA-dependent
		cellular component	intracellular
			membrane
		molecular function	muscarinic acetylcholine receptor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.