MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

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Showing element 1651 to 1700 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]	4.40598	molecular function	GMP reductase activity
			metal ion binding
			oxidoreductase activity
			potassium ion binding
Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]	1.45148	biological process	Golgi organization and biogenesis
			regulation of transcription, DNA-dependent
			vesicle-mediated transport
		cellular component	ER-Golgi intermediate compartment
			Golgi apparatus
			Golgi membrane
			Golgi stack
			integral to membrane
			membrane
			nucleus
		molecular function	DNA binding
			protein binding
GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]	3.64872	biological process	intracellular protein transport
			locomotory behavior
			nucleocytoplasmic transport
			protein transport
			signal transduction
			small GTPase mediated signal transduction
		cellular component	cellular_component
			intracellular
			membrane
		molecular function	GTP binding
			GTPase activity
			nucleotide binding
			protein binding
GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]	1.40602	biological process	ER to Golgi vesicle-mediated transport
			intracellular protein transport
			small GTPase mediated signal transduction
		cellular component	cytoplasm
			endoplasmic reticulum
			Golgi apparatus
			intracellular
		molecular function	GTP binding
			GTPase activity
			nucleotide binding
Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	1.18489	biological process	cGMP biosynthetic process
			cyclic nucleotide biosynthetic process
			intracellular signaling cascade
		cellular component	cytoplasm
		molecular function	guanylate cyclase activity
			heme binding
			iron ion binding
			metal ion binding
			phosphorus-oxygen lyase activity
Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	2.2939	biological process	organelle organization and biogenesis
			pigmentation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.