MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene Ontology	Gene	Regulation	Accession	Class	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1651 to 1700 of 2667 in total

description	Ratio	Gene Ontology	Regulation	Class
Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	1.18096	microsome	down	cellular component
		negative regulation of cell proliferation		biological process
		nucleus		cellular component
		oxidoreductase activity		molecular function
		oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
		peroxidase activity
		prostaglandin-endoperoxide synthase activity
		protein binding
		protein complex		cellular component
		regulation of inflammatory response		biological process
		regulation of progression through cell cycle
		response to oxidative stress
Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]	1.12417	enzyme binding	up	molecular function
		membrane		cellular component
		protein heterodimerization activity		molecular function
		protein homooligomerization		biological process
		protein localization
		response to metal ion
		retinoic acid receptor binding		molecular function
		retinoid-X receptor activity
		thyroid hormone receptor binding
		thyroid hormone receptor coactivator activity
		vitamin D receptor binding
Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]	1.25205	7S RNA binding	down
		GTP binding
		membrane		cellular component
		nuclear mRNA splicing, via spliceosome		biological process
		nucleus		cellular component
		RNA binding		molecular function
		RNA splicing		biological process
		spliceosome		cellular component
		SRP-dependent cotranslational protein targeting to membrane		biological process
Protein DmX-like 2 (Rabconnectin-3). [Uniprot/SWISSPROT;Acc:Q8TDJ6]	1.34001	cell junction	up	cellular component
		cytoplasmic vesicle
		membrane
		Rab GTPase binding		molecular function
		synapse		cellular component
		synaptic vesicle
Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]	1.79094	binding		molecular function
		intracellular		cellular component
		signal transduction		biological process
Protein FAM73B. [Uniprot/SPTREMBL;Acc:Q7L4E1]	1.22694	type I hypersensitivity
Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]	1.83496	ceramide metabolic process
		cytoplasm		cellular component
		receptor signaling protein activity		molecular function
		signal transduction		biological process
		soluble fraction		cellular component
Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]	2.96739	nucleus
		protein binding		molecular function
Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]	2.57202	integral to membrane		cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.