MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1601 to 1650 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	1.11519	biological process	translational initiation
		cellular component	cytoplasm
		molecular function	RNA binding
			translation initiation factor activity
Fc receptor-like 1 [RefSeq_peptide;Acc:NP_443170]	1.31895		receptor activity
Fibroblast growth factor-binding protein 3 precursor (FGF-binding protein 3) (FGF-BP3) (FGFBP-3). [Uniprot/SWISSPROT;Acc:Q8TAT2]	1.18263		growth factor binding
Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]	1.57088	biological process	caudate nucleus development
			putamen development
			regulation of transcription, DNA-dependent
			transcription
		cellular component	intracellular
			nucleus
		molecular function	metal ion binding
			nucleic acid binding
			protein homodimerization activity
			sequence-specific DNA binding
			transcription factor activity
			zinc ion binding
GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Uniprot/SWISSPROT;Acc:Q99501]	1.10233	biological process	cell cycle arrest
		cellular component	cytoplasm
			cytoskeleton
GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]	1.69345	biological process	regulation of transcription
			regulation of transcription, DNA-dependent
		cellular component	nucleus
		molecular function	DNA binding
			RNA polymerase II transcription factor activity
			transcription factor activity
Geminin. [Uniprot/SWISSPROT;Acc:O75496]	1.35125	biological process	cell cycle
			negative regulation of DNA replication
			negative regulation of progression through cell cycle
			organ morphogenesis
			regulation of progression through cell cycle
		cellular component	nucleus
		molecular function	protein binding
Glutathione peroxidase 6 precursor (EC 1.11.1.9). [Uniprot/SWISSPROT;Acc:P59796]	3.74971	biological process	response to oxidative stress
		molecular function	glutathione peroxidase activity
			oxidoreductase activity
			selenium binding
Glycerophosphodiester phosphodiesterase domain-containing protein 2 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 3) (Osteoblast differentiation promoting factor). [Uniprot/SWISSPROT;Acc:Q9HCC8]	1.37801	biological process	glycerol metabolic process
			metabolic process
		cellular component	cytoplasm
			cytoskeleton
			integral to membrane
			membrane
		molecular function	glycerophosphodiester phosphodiesterase activity
			hydrolase activity
GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]	4.40598	biological process	metabolic process
			nucleotide metabolic process
			response to cold
		molecular function	catalytic activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.