MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 255 to 304 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.27696	Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	biological process	G1/S transition of mitotic cell cycle
			multicellular organismal development
			positive regulation of cell proliferation
			positive regulation of cyclin-dependent protein kinase activity
			protein amino acid dephosphorylation
			regulation of progression through cell cycle
			response to DNA damage stimulus
		cellular component	nucleus
		molecular function	protein binding
			protein kinase binding
			protein phosphatase type 1 activity
1.27802	Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]	biological process	homoiothermy
			response to freezing
		molecular function	ice binding
			protein binding
1.28356	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]	biological process	cardiac muscle development
			cell aging
			heart morphogenesis
			homoiothermy
			mammary gland development
			multicellular organismal development
			muscle cell fate determination
			negative regulation of transcription from RNA polymerase II promoter
			positive regulation of cell proliferation
			regulation of transcription, DNA-dependent
			response to freezing
			transcription
			transport
		cellular component	membrane
			nucleus
			transcription factor complex
		molecular function	ice binding
			nucleoside transporter activity
			protein binding
			sequence-specific DNA binding
			transcription factor activity
			transcriptional repressor activity
1.28805	ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	biological process	proteolysis
		cellular component	extracellular matrix
			proteinaceous extracellular matrix
		molecular function	metal ion binding
			metalloendopeptidase activity
			metallopeptidase activity
			peptidase activity
			zinc ion binding
1.29424	Calcyphosin-2 (Calcyphosine-2). [Uniprot/SWISSPROT;Acc:Q9BXY5]	biological process	ciliary or flagellar motility
		cellular component	flagellin-based flagellum
		molecular function	calcium ion binding
1.2984	nucleolar and spindle associated protein 1 isoform 2 [RefSeq_peptide;Acc:NP_060924]	biological process	cytokinesis after mitosis
			establishment of mitotic spindle localization

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.