MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1601 to 1650 of 2667 in total

description	Ratio	Regulation	Gene Ontology	Class
POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Uniprot/SWISSPROT;Acc:Q16633]	1.44789	up	DNA binding	molecular function
			humoral immune response	biological process
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcription coactivator activity	molecular function
			transcription from RNA polymerase II promoter	biological process
Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]	3.43019	down	biological_process
			mRNA processing
			nucleus	cellular component
			protein binding	molecular function
			RNA splicing	biological process
			spliceosome	cellular component
Probable fibrosin-1 long transcript protein. [Uniprot/SWISSPROT;Acc:Q9HAH7]	3.26367	up	homoiothermy	biological process
			ice binding	molecular function
			response to freezing	biological process
			type I hypersensitivity
Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]	1.10831		collagen binding	molecular function
			multicellular organismal development	biological process
Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). [Uniprot/SWISSPROT;Acc:Q8N4S7]	3.76904		integral to membrane	cellular component
			membrane
			receptor activity	molecular function
Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]	1.74736	down	cytoplasm	cellular component
			membrane
Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	1.19134		calcium ion binding	molecular function
			cell-cell signaling	biological process
			determination of left/right symmetry
			endoplasmic reticulum	cellular component
			intracellular
			membrane
			nucleic acid binding	molecular function
			peptidase activity
			proteolysis	biological process
			subtilase activity	molecular function
			zinc ion binding
			zygotic determination of anterior/posterior axis, embryo	biological process
Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	1.18096		anagen
			blood pressure regulation
			caveolar membrane	cellular component
			cell motility	biological process
			cyclooxygenase pathway
			cytoplasm	cellular component
			electron transport	biological process
			endoplasmic reticulum	cellular component
			fatty acid biosynthetic process	biological process
			heme binding	molecular function
			iron ion binding
			membrane	cellular component
			metal ion binding	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.