MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1600 to 1649 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	1.17879	up	molecular function	voltage-gated potassium channel activity
POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Uniprot/SWISSPROT;Acc:Q16633]	1.44789		biological process	humoral immune response
				regulation of transcription, DNA-dependent
				transcription
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	DNA binding
				protein binding
				transcription coactivator activity
Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]	3.43019	down	biological process	biological_process
				mRNA processing
				RNA splicing
			cellular component	nucleus
				spliceosome
			molecular function	protein binding
Probable fibrosin-1 long transcript protein. [Uniprot/SWISSPROT;Acc:Q9HAH7]	3.26367	up	biological process	homoiothermy
				response to freezing
				type I hypersensitivity
			molecular function	ice binding
Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]	1.10831		biological process	multicellular organismal development
			molecular function	collagen binding
Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). [Uniprot/SWISSPROT;Acc:Q8N4S7]	3.76904		cellular component	integral to membrane
				membrane
			molecular function	receptor activity
Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]	1.74736	down	cellular component	cytoplasm
				membrane
Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	1.19134		biological process	cell-cell signaling
				determination of left/right symmetry
				proteolysis
				zygotic determination of anterior/posterior axis, embryo
			cellular component	endoplasmic reticulum
				intracellular
				membrane
			molecular function	calcium ion binding
				nucleic acid binding
				peptidase activity
				subtilase activity
				zinc ion binding
Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	1.18096		biological process	anagen
				blood pressure regulation
				cell motility
				cyclooxygenase pathway
				electron transport
				fatty acid biosynthetic process
				negative regulation of cell proliferation
				regulation of inflammatory response
				regulation of progression through cell cycle
				response to oxidative stress
			cellular component	caveolar membrane
				cytoplasm

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.