MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1593 to 1642 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
1.80858	down	biological process	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	signal transduction
		cellular component		intracellular
		molecular function		protein binding
				small GTPase regulator activity
1.80942		cellular component	Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	integral to membrane
				membrane
1.81557		biological process	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	homoiothermy
				response to freezing
		cellular component		nucleus
		molecular function		ATP binding
				DNA binding
				helicase activity
				hydrolase activity
				ice binding
				nucleic acid binding
				nucleotide binding
1.82063		cellular component	Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	integral to membrane
				membrane
1.82311		biological process	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	cell proliferation
				cell-cell signaling
				fibroblast growth factor receptor signaling pathway
				glial cell differentiation
				nervous system development
				regulation of progression through cell cycle
		cellular component		extracellular space
		molecular function		growth factor activity
1.83496	up	biological process	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]	ceramide metabolic process
				signal transduction
		cellular component		cytoplasm
				soluble fraction
		molecular function		receptor signaling protein activity
1.83601		biological process	coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]	G-protein coupled receptor protein signaling pathway
		cellular component		integral to membrane
				membrane
				mitochondrion
1.86204	down	biological process	Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]	regulation of transcription, DNA-dependent
				transcription
		cellular component		intracellular
				nucleus
		molecular function		metal ion binding
				nucleic acid binding
				transcription factor activity
				zinc ion binding
1.86433	up	biological process	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]	cation transport
				chemotaxis
		cellular component		extracellular space
				integral to membrane
				membrane
		molecular function		ATP binding
				ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.