MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1569 to 1618 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.30407	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]	biological process	axonogenesis
			multicellular organismal development
			regulation of transcription, DNA-dependent
			transcription from RNA polymerase II promoter
		cellular component	nucleus
		molecular function	RNA polymerase II transcription factor activity
			sequence-specific DNA binding
			transcription factor activity
1.31661	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]	biological process	anion transport
			cytochrome complex assembly
			excretion
			heme transport
			sulfate transport
			transport
		cellular component	apical plasma membrane
			brush border membrane
			integral to membrane
			membrane
			membrane fraction
		molecular function	anion exchanger activity
			antiporter activity
			chloride ion binding
			heme transporter activity
			sulfate porter activity
			transcription cofactor activity
			transcription factor activity
			transporter activity
1.31895	Fc receptor-like 1 [RefSeq_peptide;Acc:NP_443170]		receptor activity
1.33329	Beta-mannosidase precursor (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase). [Uniprot/SWISSPROT;Acc:O00462]	biological process	carbohydrate metabolic process
			glycoprotein catabolic process
			metabolic process
			protein modification process
		cellular component	lysosome
		molecular function	beta-mannosidase activity
			cation binding
			hydrolase activity, hydrolyzing O-glycosyl compounds
1.33465	T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]	biological process	cell-cell signaling
			embryonic arm morphogenesis
			embryonic limb morphogenesis
			forelimb morphogenesis
			heart development
			induction of apoptosis
			lung development
			morphogenesis of an epithelium
			multicellular organismal development
			negative regulation of cardiac muscle cell proliferation
			negative regulation of cell migration
			pattern specification process
			pericardium development
			positive regulation of cardioblast differentiation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.