MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	description	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1569 to 1618 of 2667 in total

Ratio	description	Regulation	Class	Gene Ontology
1.78439	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	up	molecular function	ATP binding
				ATP-dependent DNA helicase activity
				ATP-dependent helicase activity
				chromatin binding
				DNA binding
				helicase activity
				hydrolase activity
				metal ion binding
				nucleic acid binding
				nucleotide binding
				protein binding
				transcription factor binding
				zinc ion binding
1.78708	Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]		cellular component	chromosome
				chromosome, pericentric region
				nucleus
1.79094	Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]		biological process	signal transduction
			cellular component	intracellular
			molecular function	binding
1.7961	RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]		biological process	protein transport
				small GTPase mediated signal transduction
			cellular component	intracellular
			molecular function	GTP binding
				nucleotide binding
1.80858	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	down	biological process	signal transduction
			cellular component	intracellular
			molecular function	protein binding
				small GTPase regulator activity
1.80942	Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]		cellular component	integral to membrane
				membrane
1.81557	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]		biological process	homoiothermy
				response to freezing
			cellular component	nucleus
			molecular function	ATP binding
				DNA binding
				helicase activity
				hydrolase activity
				ice binding
				nucleic acid binding
				nucleotide binding
1.82063	Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]		cellular component	integral to membrane
				membrane
1.82311	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]		biological process	cell proliferation
				cell-cell signaling
				fibroblast growth factor receptor signaling pathway
				glial cell differentiation
				nervous system development
				regulation of progression through cell cycle
			cellular component	extracellular space
			molecular function	growth factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.