MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1569 to 1618 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
1.78439	up	molecular function	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	ATP binding
				ATP-dependent DNA helicase activity
				ATP-dependent helicase activity
				chromatin binding
				DNA binding
				helicase activity
				hydrolase activity
				metal ion binding
				nucleic acid binding
				nucleotide binding
				protein binding
				transcription factor binding
				zinc ion binding
1.78708		cellular component	Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]	chromosome
				chromosome, pericentric region
				nucleus
1.79094		biological process	Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]	signal transduction
		cellular component		intracellular
		molecular function		binding
1.7961		biological process	RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]	protein transport
				small GTPase mediated signal transduction
		cellular component		intracellular
		molecular function		GTP binding
				nucleotide binding
1.80858	down	biological process	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	signal transduction
		cellular component		intracellular
		molecular function		protein binding
				small GTPase regulator activity
1.80942		cellular component	Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	integral to membrane
				membrane
1.81557		biological process	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	homoiothermy
				response to freezing
		cellular component		nucleus
		molecular function		ATP binding
				DNA binding
				helicase activity
				hydrolase activity
				ice binding
				nucleic acid binding
				nucleotide binding
1.82063		cellular component	Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	integral to membrane
				membrane
1.82311		biological process	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	cell proliferation
				cell-cell signaling
				fibroblast growth factor receptor signaling pathway
				glial cell differentiation
				nervous system development
				regulation of progression through cell cycle
		cellular component		extracellular space
		molecular function		growth factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.