MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1501 to 1550 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]	1.63639	cellular component	cytoplasmic vesicle
			Golgi apparatus
			Golgi-associated vesicle
			plasma membrane
		molecular function	molecular_function
Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	2.69364	biological process	anterior/posterior pattern formation
			central nervous system development
			electron transport
			metabolic process
			neural crest cell development
			retinoic acid metabolic process
			retinoic acid receptor signaling pathway
		cellular component	endoplasmic reticulum
			membrane
			microsome
		molecular function	heme binding
			iron ion binding
			metal ion binding
			monooxygenase activity
			oxygen binding
			retinoic acid 4-hydroxylase activity
Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]	1.49264	biological process	electron transport
		cellular component	endoplasmic reticulum
			membrane
		molecular function	heme binding
			iron ion binding
			metal ion binding
			monooxygenase activity
			oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]	1.25729	biological process	enterobactin biosynthetic process
			metabolic process
		cellular component	endoplasmic reticulum
			mitochondrial inner membrane
		molecular function	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
			oxidoreductase activity
Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	1.19545	biological process	apoptosis
			DNA catabolic process
			DNA metabolic process
			erythrocyte differentiation
			multicellular organismal development
		cellular component	extracellular region
			lysosome
		molecular function	deoxyribonuclease II activity
			DNA binding
			endodeoxyribonuclease activity
			endonuclease activity
			hormone activity
			hydrolase activity
			protein binding
Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]	3.31364	biological process	glycerol metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.