MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Ratio	Gene Ontology	Gene	Class	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1501 to 1550 of 2667 in total

description	Regulation	Ratio	Gene Ontology	Class
Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2). [Uniprot/SWISSPROT;Acc:Q9H1P3]	up	2.43098	lipid transport	biological process
			steroid metabolic process
Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]		4.55371	cytoplasm	cellular component
			G-protein coupled receptor activity	molecular function
			G-protein signaling, coupled to cyclic nucleotide second messenger	biological process
			integral to membrane	cellular component
			integral to plasma membrane
			membrane
			nucleus
			parathyroid hormone receptor activity	molecular function
			receptor activity
			signal transduction	biological process
			skeletal development
PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]		5.81102	cell surface	cellular component
			cytoplasm
			cytoskeleton
			metal ion binding	molecular function
			nucleus	cellular component
			protein binding	molecular function
			zinc ion binding
Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]	down	1.58045	integral to peroxisomal membrane	cellular component
			integral to plasma membrane
			membrane
			peroxisomal membrane
			peroxisome
			peroxisome organization and biogenesis	biological process
			protein binding	molecular function
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Uniprot/SWISSPROT;Acc:Q14442]		1.55809	cytoplasm	cellular component
			endoplasmic reticulum
			GPI anchor biosynthetic process	biological process
			phosphatidylinositol N-acetylglucosaminyltransferase activity	molecular function
			protein modification process	biological process
			transferase activity, transferring glycosyl groups	molecular function
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]		5.23046	1-phosphatidylinositol-3-kinase activity
			G-protein coupled receptor protein signaling pathway	biological process
			inositol or phosphatidylinositol kinase activity	molecular function
			negative regulation of apoptosis	biological process
			phosphatidylinositol-4,5-bisphosphate 3-kinase activity	molecular function
			phosphoinositide 3-kinase complex	cellular component
			phosphoinositide phosphorylation	biological process
			phosphoinositide-mediated signaling
			phosphotransferase activity, alcohol group as acceptor	molecular function
			protein amino acid phosphorylation	biological process
			protein binding	molecular function
			transferase activity
Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	up	1.17693	biological_process	biological process
			cellular_component	cellular component
			cytoplasm
			lipid binding	molecular function
			membrane	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.