MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 151 to 200 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.16499	up	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	zinc ion binding	molecular function
1.16823		S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]	cell proliferation	biological process
			G1/S transition of mitotic cell cycle
			protein binding	molecular function
			regulation of progression through cell cycle	biological process
			ubiquitin cycle
1.16921		Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]	cell differentiation
			DNA binding	molecular function
			multicellular organismal development	biological process
			nervous system development
			nucleus	cellular component
			regulation of transcription	biological process
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
			transcription cofactor activity	molecular function
			transcription factor activity
			transcription factor complex	cellular component
			transcription regulator activity	molecular function
1.17398		Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Uniprot/SWISSPROT;Acc:O75356]	calcium ion binding
			endoplasmic reticulum	cellular component
			hydrolase activity	molecular function
			integral to membrane	cellular component
			magnesium ion binding	molecular function
			membrane	cellular component
			nucleoside-diphosphatase activity	molecular function
1.17693		Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	biological_process	biological process
			cellular_component	cellular component
			cytoplasm
			lipid binding	molecular function
			membrane	cellular component
			phosphatidylinositol binding	molecular function
1.17859	down	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]	integral to membrane	cellular component
			membrane
1.17879	up	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	inner ear morphogenesis	biological process
			ion channel activity	molecular function
			ion transport	biological process
			membrane	cellular component
			membrane fraction
			potassium ion binding	molecular function
			potassium ion transport	biological process
			sensory perception of sound
			voltage-gated ion channel activity	molecular function
			voltage-gated potassium channel activity
			voltage-gated potassium channel complex	cellular component
1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	anagen	biological process
			blood pressure regulation
			caveolar membrane	cellular component
			cell motility	biological process
			cyclooxygenase pathway
			cytoplasm	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.