MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1490 to 1539 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.69856	up	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	molecular function	protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
1.72628	down	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]	biological process	DNA repair
			cellular component	integral to membrane
				membrane
			molecular function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
				structural molecule activity
1.72656		protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	biological process	ER overload response
				response to hydrogen peroxide
				response to oxidative stress
			cellular component	protein phosphatase type 1 complex
			molecular function	protein serine/threonine phosphatase activity
1.73211		Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	biological process	cell cycle
				cell proliferation
				meiosis
				regulation of progression through cell cycle
			cellular component	chromosome, pericentric region
				condensed chromosome
				cytoplasm
				nucleolus
				nucleus
			molecular function	ATP binding
				nucleotide binding
				protein binding
1.73291	up	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	biological process	potassium ion transport
			cellular component	membrane
				voltage-gated potassium channel complex
			molecular function	protein binding
				voltage-gated potassium channel activity
1.74736	down	Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]	cellular component	cytoplasm
				membrane
1.75026	up	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	biological process	axon ensheathment
				calcium-independent cell-cell adhesion
				cell adhesion
				spermatogenesis
			cellular component	cell junction
				integral to membrane
				membrane
				tight junction
			molecular function	identical protein binding
				structural molecule activity
1.75846	down	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	biological process	amino acid metabolic process
				L-cystine transport
				transport
			cellular component	integral to membrane
				lysosomal membrane
				lysosome
				membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.