MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1490 to 1539 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.69856	up	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	protein kinase activity	molecular function
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
1.72628	down	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]	DNA repair	biological process
			integral to membrane	cellular component
			membrane
			methylated-DNA-[protein]-cysteine S-methyltransferase activity	molecular function
			structural molecule activity
1.72656		protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	ER overload response	biological process
			protein phosphatase type 1 complex	cellular component
			protein serine/threonine phosphatase activity	molecular function
			response to hydrogen peroxide	biological process
			response to oxidative stress
1.73211		Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	ATP binding	molecular function
			cell cycle	biological process
			cell proliferation
			chromosome, pericentric region	cellular component
			condensed chromosome
			cytoplasm
			meiosis	biological process
			nucleolus	cellular component
			nucleotide binding	molecular function
			nucleus	cellular component
			protein binding	molecular function
			regulation of progression through cell cycle	biological process
1.73291	up	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	membrane	cellular component
			potassium ion transport	biological process
			protein binding	molecular function
			voltage-gated potassium channel activity
			voltage-gated potassium channel complex	cellular component
1.74736	down	Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]	cytoplasm
			membrane
1.75026	up	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	axon ensheathment	biological process
			calcium-independent cell-cell adhesion
			cell adhesion
			cell junction	cellular component
			identical protein binding	molecular function
			integral to membrane	cellular component
			membrane
			spermatogenesis	biological process
			structural molecule activity	molecular function
			tight junction	cellular component
1.75846	down	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	amino acid metabolic process	biological process
			integral to membrane	cellular component
			L-cystine transport	biological process
			L-cystine transporter activity	molecular function
			lysosomal membrane	cellular component
			lysosome
			membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.