MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	Class	description	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1453 to 1502 of 2667 in total

Ratio	Regulation	Gene Ontology	Class	description
1.66679	up	protein amino acid ADP-ribosylation	biological process	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]
		protein binding	molecular function
		transferase activity, transferring glycosyl groups
		zinc ion binding
1.683	down	cytoplasm	cellular component	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]
		exonuclease activity	molecular function
		exosome (RNase complex)	cellular component
		GDP-dissociation stimulator activity	molecular function
		hydrolase activity
		nucleus	cellular component
		ribonuclease activity	molecular function
		RNA binding
		rRNA processing	biological process
1.69153		intermediate filament	cellular component	Keratin-associated protein 19-2. [Uniprot/SWISSPROT;Acc:Q3LHN2]
1.693		catalytic activity	molecular function	CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]
		iron-sulfur cluster binding
		metabolic process	biological process
1.69345	up	DNA binding	molecular function	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]
		nucleus	cellular component
		regulation of transcription	biological process
		regulation of transcription, DNA-dependent
		RNA polymerase II transcription factor activity	molecular function
		transcription factor activity
1.69658	down	beta-galactoside alpha-2,3-sialyltransferase activity		CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]
		Golgi apparatus	cellular component
		integral to Golgi membrane
		integral to membrane
		membrane
		protein amino acid glycosylation	biological process
		sialyltransferase activity	molecular function
		transferase activity, transferring glycosyl groups
1.69856	up	ATP binding		Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]
		calmodulin binding
		cytoplasm	cellular component
		neuromuscular synaptic transmission	biological process
		nucleotide binding	molecular function
		protein amino acid phosphorylation	biological process
		protein kinase activity	molecular function
		protein serine/threonine kinase activity
		protein-tyrosine kinase activity
		transferase activity
1.72628	down	DNA repair	biological process	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]
		integral to membrane	cellular component
		membrane
		methylated-DNA-[protein]-cysteine S-methyltransferase activity	molecular function
		structural molecule activity
1.72656		ER overload response	biological process	protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]
		protein phosphatase type 1 complex	cellular component
		protein serine/threonine phosphatase activity	molecular function
		response to hydrogen peroxide	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.