MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene	Regulation	Class	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 143 to 192 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	1.50284	down	cellular component	membrane coat
			molecular function	protein binding
				protein transporter activity
Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]	1.63713	up	cellular component	integral to membrane
				membrane
			molecular function	binding
Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]	3.00923	down	biological process	metabolic process
			cellular component	cytoplasm
			molecular function	acetyltransferase activity
				arylamine N-acetyltransferase activity
				transferase activity
Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245]	4.69231		biological process	metabolic process
			cellular component	cytoplasm
			molecular function	acetyltransferase activity
				arylamine N-acetyltransferase activity
				transferase activity
AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	3.83977		biological process	multicellular organismal development
				regulation of transcription
				transcription
			cellular component	cytoplasm
				nuclear matrix
				nucleus
			molecular function	DNA binding
				transcription factor activity
Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]	2.29381	up	biological process	cell death
				nuclear organization and biogenesis
				visual perception
			cellular component	cytoplasm
				intracellular
				nucleus
			molecular function	chromatin binding
				protein binding
				zinc ion binding
Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Uniprot/SWISSPROT;Acc:Q8NHH9]	1.24964	down	biological process	immune response
			cellular component	integral to membrane
				membrane
			molecular function	GTP binding
				GTPase activity
				nucleotide binding
				protein binding
ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	1.22502	up	biological process	response to drug
				transport
			cellular component	integral to membrane
				lamellar body
				membrane fraction
				plasma membrane
			molecular function	ATP binding
				ATPase activity
				ATPase activity, coupled to transmembrane movement of substances
				nucleoside-triphosphatase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.