MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1400 to 1449 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.62709	up	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	biological process	dephosphorylation
				protein amino acid dephosphorylation
			cellular component	cytoplasmic vesicle
			molecular function	hydrolase activity
				phosphoric monoester hydrolase activity
				protein tyrosine phosphatase activity
1.63639		Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]	biological process	biological_process
			cellular component	cellular_component
				cytoplasmic vesicle
				Golgi apparatus
				Golgi-associated vesicle
				plasma membrane
			molecular function	molecular_function
1.63713		Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]	cellular component	integral to membrane
				membrane
			molecular function	binding
1.6384		Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]	biological process	G-protein coupled receptor protein signaling pathway
				signal transduction
			cellular component	integral to membrane
				membrane
			molecular function	olfactory receptor activity
				receptor activity
				rhodopsin-like receptor activity
1.63945		Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK). [Uniprot/SWISSPROT;Acc:P31152]	biological process	cell cycle
				protein amino acid phosphorylation
			molecular function	ATP binding
				MAP kinase activity
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
1.65422		Uncharacterized protein C9orf117. [Uniprot/SPTREMBL;Acc:Q5JU67]	biological process	signal transduction
			cellular component	intracellular
1.65835	down	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	biological process	selenocysteine incorporation
				translational elongation
			cellular component	cytoplasm
				nucleus
			molecular function	GTP binding
				GTPase activity
				nucleotide binding
				translation elongation factor activity
				tRNA binding
1.66123	up	KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]	biological process	G-protein coupled receptor protein signaling pathway
				regulation of transcription, DNA-dependent
			cellular component	intracellular
				membrane
			molecular function	muscarinic acetylcholine receptor activity
				nucleic acid binding
1.66679		TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	biological process	protein amino acid ADP-ribosylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.