MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1300 to 1349 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	1.35022	up	molecular function	oxidized purine base lesion DNA N-glycosylase activity
				protein binding
Nck-associated protein 1-like (Membrane-associated protein HEM-1) (Hematopoietic protein 1). [Uniprot/SWISSPROT;Acc:P55160]	1.47697		cellular component	integral to plasma membrane
				membrane
				membrane fraction
NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]	3.21581			cytoplasm
			molecular function	ATP binding
				ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
				endonuclease activity
				hydrolase activity
				nucleotide binding
				protein binding
Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	1.2734		biological process	cell adhesion
				neurotransmitter secretion
				synaptic transmission
				synaptogenesis
			cellular component	integral to membrane
				membrane
			molecular function	calcium channel regulator activity
				calcium ion binding
				protein binding
Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]	2.54508		biological process	cell adhesion
				cell-cell adhesion
				intercellular junction maintenance
				synaptogenesis
			cellular component	integral to membrane
				membrane
				postsynaptic membrane
				synapse
			molecular function	cholinesterase activity
				neurexin binding
Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]	1.20481	down	biological process	biological_process
				generation of precursor metabolites and energy
				ovarian follicle development
				sexual reproduction
			cellular component	cellular_component
				cytoplasmic vesicle
			molecular function	growth factor activity
				neuropeptide hormone activity
Ninein-like protein. [Uniprot/SWISSPROT;Acc:Q9Y2I6]	3.15011		cellular component	cytoplasm
				microtubule
			molecular function	calcium ion binding
Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]	5.32612		biological process	cellular respiration
				heart development
				inflammatory response
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
			cellular component	cytoplasm
				nucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.