MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1290 to 1339 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]	2.87038	biological process	sarcomere organization
		cellular component	cytoplasm
			intracellular
			nucleus
		molecular function	calcium ion binding
			calpain activity
			cysteine-type endopeptidase activity
			peptidase activity
			protein binding
			signal transducer activity
Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	2.70687	biological process	homoiothermy
			response to freezing
			translation
		cellular component	intracellular
			ribosome
		molecular function	calcium ion binding
			ice binding
			structural constituent of ribosome
CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]	1.98149	biological process	anti-apoptosis
			B cell differentiation
			B cell proliferation
			immune response
			inflammatory response
			isotype switching
			leukocyte adhesion
			platelet activation
			regulation of immunoglobulin secretion
		cellular component	extracellular space
			integral to membrane
			integral to plasma membrane
			membrane
			soluble fraction
		molecular function	CD40 receptor binding
			cytokine activity
			tumor necrosis factor receptor binding
Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]	1.78708	cellular component	chromosome
			chromosome, pericentric region
			nucleus
Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]	2.7017	biological process	chromosome organization and biogenesis (sensu Eukaryota)
			G-protein signaling, adenylate cyclase inhibiting pathway
			nucleosome assembly
			synaptic transmission
		cellular component	chromosome
			chromosome, pericentric region
			extracellular region
			nucleosome
			nucleus
			soluble fraction
		molecular function	DNA binding
			G-protein-coupled receptor binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.