MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1290 to 1339 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	1.35022	up	cellular component	intracellular
				mitochondrion
				nucleoplasm
				nucleus
			molecular function	damaged DNA binding
				DNA binding
				endonuclease activity
				hydrolase activity, acting on glycosyl bonds
				lyase activity
				microtubule binding
				oxidized purine base lesion DNA N-glycosylase activity
				protein binding
Nck-associated protein 1-like (Membrane-associated protein HEM-1) (Hematopoietic protein 1). [Uniprot/SWISSPROT;Acc:P55160]	1.47697		cellular component	integral to plasma membrane
				membrane
				membrane fraction
NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]	3.21581			cytoplasm
			molecular function	ATP binding
				ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
				endonuclease activity
				hydrolase activity
				nucleotide binding
				protein binding
Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	1.2734		biological process	cell adhesion
				neurotransmitter secretion
				synaptic transmission
				synaptogenesis
			cellular component	integral to membrane
				membrane
			molecular function	calcium channel regulator activity
				calcium ion binding
				protein binding
Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]	2.54508		biological process	cell adhesion
				cell-cell adhesion
				intercellular junction maintenance
				synaptogenesis
			cellular component	integral to membrane
				membrane
				postsynaptic membrane
				synapse
			molecular function	cholinesterase activity
				neurexin binding
Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]	1.20481	down	biological process	biological_process
				generation of precursor metabolites and energy
				ovarian follicle development
				sexual reproduction
			cellular component	cellular_component
				cytoplasmic vesicle
			molecular function	growth factor activity
				neuropeptide hormone activity
Ninein-like protein. [Uniprot/SWISSPROT;Acc:Q9Y2I6]	3.15011		cellular component	cytoplasm

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.