MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1251 to 1300 of 2667 in total

description	Ratio	Regulation	Gene Ontology	Class
Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	2.58329	down	nervous system development	biological process
			nucleus	cellular component
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcription factor activity	molecular function
			zinc ion binding
Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	1.69856	up	ATP binding
			calmodulin binding
			cytoplasm	cellular component
			neuromuscular synaptic transmission	biological process
			nucleotide binding	molecular function
			protein amino acid phosphorylation	biological process
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	1.24114	down	actin binding
			ATP binding
			calmodulin binding
			intracellular	cellular component
			motor activity	molecular function
			myosin complex	cellular component
			nucleotide binding	molecular function
			signal transduction	biological process
			striated muscle contraction
			striated muscle thick filament	cellular component
Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	1.23668		actin binding	molecular function
			ATP binding
			biological_process	biological process
			calmodulin binding	molecular function
			motor activity
			myosin complex	cellular component
			nucleoside-triphosphatase activity	molecular function
			nucleotide binding
			unconventional myosin complex	cellular component
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	1.35022	up	base-excision repair	biological process
			cellular_component	cellular component
			damaged DNA binding	molecular function
			DNA binding
			DNA repair	biological process
			endonuclease activity	molecular function
			hydrolase activity, acting on glycosyl bonds
			intracellular	cellular component
			lyase activity	molecular function
			metabolic process	biological process
			microtubule binding	molecular function
			mitochondrion	cellular component
			nucleoplasm
			nucleus
			oxidized purine base lesion DNA N-glycosylase activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.