MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1251 to 1300 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	2.58329	down	biological process	transcription
			cellular component	nucleus
			molecular function	calcium ion binding
				metal ion binding
				transcription factor activity
				zinc ion binding
Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	1.69856	up	biological process	neuromuscular synaptic transmission
				protein amino acid phosphorylation
			cellular component	cytoplasm
			molecular function	ATP binding
				calmodulin binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	1.24114	down	biological process	signal transduction
				striated muscle contraction
			cellular component	intracellular
				myosin complex
				striated muscle thick filament
			molecular function	actin binding
				ATP binding
				calmodulin binding
				motor activity
				nucleotide binding
Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	1.23668		biological process	biological_process
			cellular component	myosin complex
				unconventional myosin complex
			molecular function	actin binding
				ATP binding
				calmodulin binding
				motor activity
				nucleoside-triphosphatase activity
				nucleotide binding
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	1.35022	up	biological process	base-excision repair
				DNA repair
				metabolic process
			cellular component	cellular_component
				intracellular
				mitochondrion
				nucleoplasm
				nucleus
			molecular function	damaged DNA binding
				DNA binding
				endonuclease activity
				hydrolase activity, acting on glycosyl bonds
				lyase activity
				microtubule binding
				oxidized purine base lesion DNA N-glycosylase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.