MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1201 to 1250 of 2667 in total

description	Ratio	Regulation	Gene Ontology	Class
MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	7.45006	down	histamine receptor activity	molecular function
			integral to membrane	cellular component
			structural constituent of cell wall	molecular function
Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]	1.27802		homoiothermy	biological process
			ice binding	molecular function
			protein binding
			response to freezing	biological process
Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]	1.29952		cytoplasm	cellular component
			nucleus
			regulation of progression through cell cycle	biological process
Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]	1.20102	up	apoptosis
			cell cycle
			copper ion binding	molecular function
			electron transport	biological process
			endosome	cellular component
			FAD binding	molecular function
			ferric-chelate reductase activity
			integral to membrane	cellular component
			ion transport	biological process
			iron ion binding	molecular function
			iron ion transport	biological process
			membrane	cellular component
			metal ion binding	molecular function
			oxidoreductase activity
			plasma membrane	cellular component
Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	1.22576		DNA binding	molecular function
			metal ion binding
			methyl-CpG binding
			negative regulation of transcription	biological process
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcription corepressor activity	molecular function
			transcription factor activity
			transcription from RNA polymerase II promoter	biological process
			zinc ion binding	molecular function
Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK). [Uniprot/SWISSPROT;Acc:P31152]	1.63945		ATP binding
			cell cycle	biological process
			MAP kinase activity	molecular function
			nucleotide binding
			protein amino acid phosphorylation	biological process
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	2.58329	down	calcium ion binding
			cell differentiation	biological process
			metal ion binding	molecular function
			multicellular organismal development	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.