MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1190 to 1239 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	1.24361	down	molecular function	mannosidase activity
				mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10). [Uniprot/SWISSPROT;Acc:P27448]	1.34969	up	biological process	protein amino acid phosphorylation
			molecular function	ATP binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	7.45006	down	biological process	G-protein coupled receptor protein signaling pathway
			cellular component	integral to membrane
			molecular function	histamine receptor activity
				structural constituent of cell wall
Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]	1.27802		biological process	homoiothermy
				response to freezing
			molecular function	ice binding
				protein binding
Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]	1.29952		biological process	regulation of progression through cell cycle
			cellular component	cytoplasm
				nucleus
Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]	1.20102	up	biological process	apoptosis
				cell cycle
				electron transport
				ion transport
				iron ion transport
			cellular component	endosome
				integral to membrane
				membrane
				plasma membrane
			molecular function	copper ion binding
				FAD binding
				ferric-chelate reductase activity
				iron ion binding
				metal ion binding
				oxidoreductase activity
Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	1.22576		biological process	negative regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	DNA binding
				metal ion binding
				methyl-CpG binding
				protein binding
				transcription corepressor activity
				transcription factor activity
				zinc ion binding
Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK). [Uniprot/SWISSPROT;Acc:P31152]	1.63945		biological process	cell cycle
				protein amino acid phosphorylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.