MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

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Showing element 1190 to 1239 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	5.19755	cellular component	integral to membrane
			membrane
		molecular function	hormone binding
			identical protein binding
			protein heterodimerization activity
			receptor activity
Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	2.49031	biological process	nervous system development
			protein transport
		molecular function	protein binding
AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]	4.07995	biological process	insulin receptor signaling pathway
			intracellular protein transport
			protein complex assembly
			transport
			vesicle-mediated transport
		cellular component	cytoplasmic vesicle
			Golgi apparatus
			membrane
			membrane coat
			membrane coat adaptor complex
			transport vesicle
		molecular function	protein binding
			protein transporter activity
			transporter activity
Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]	1.63713	cellular component	integral to membrane
			membrane
		molecular function	binding
Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]	2.29381	biological process	cell death
			nuclear organization and biogenesis
			visual perception
		cellular component	cytoplasm
			intracellular
			nucleus
		molecular function	chromatin binding
			protein binding
			zinc ion binding
ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	1.22502	biological process	response to drug
			transport
		cellular component	integral to membrane
			lamellar body
			membrane fraction
			plasma membrane
		molecular function	ATP binding
			ATPase activity
			ATPase activity, coupled to transmembrane movement of substances
			nucleoside-triphosphatase activity
			nucleotide binding
			transporter activity
ATPase family AAA domain-containing protein 2B. [Uniprot/SWISSPROT;Acc:Q9ULI0]	1.39878		ATP binding
			nucleoside-triphosphatase activity
			nucleotide binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.