MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1143 to 1192 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	4.62042	down	biological process	protein amino acid N-linked glycosylation
				visual perception
			cellular component	integral to membrane
				integral to plasma membrane
				membrane
				plasma membrane
leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	1.76583		biological process	antigen processing and presentation of endogenous peptide antigen via MHC class I
				blood pressure regulation
				proteolysis
			cellular component	endoplasmic reticulum lumen
			molecular function	aminopeptidase activity
				membrane alanyl aminopeptidase activity
				metallopeptidase activity
				N-terminal arginine aminopeptidase activity
				N-terminal lysine aminopeptidase activity
				zinc ion binding
Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]	1.30207		biological process	cholesterol homeostasis
				cholesterol metabolic process
				endocytosis
				lipid metabolic process
				positive regulation of receptor mediated endocytosis
				regulation of protein binding
				steroid metabolic process
			cellular component	AP-1 adaptor complex
				AP-2 adaptor complex
				basal plasma membrane
				cytoplasm
				cytosol
				early endosome
			molecular function	clathrin binding
				phosphotyrosine binding
				protein binding
				protein binding, bridging
				protein C-terminus binding
				receptor signaling complex scaffold activity
				transport accessory protein activity
LRRC44 protein. [Uniprot/SPTREMBL;Acc:Q6P5P7]	3.41794	up		protein binding
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	1.24361	down	biological process	metabolic process
				protein amino acid glycosylation
			cellular component	endoplasmic reticulum
				ER-Golgi intermediate compartment
				Golgi apparatus
				integral to membrane
				membrane
				membrane fraction
			molecular function	calcium ion binding
				hydrolase activity, acting on glycosyl bonds
				mannosidase activity
				mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10). [Uniprot/SWISSPROT;Acc:P27448]	1.34969	up	biological process	protein amino acid phosphorylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.