MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1143 to 1192 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.48389	down	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]	molecular function	protein binding
				transporter activity
				zinc ion binding
1.49264	up	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]	biological process	electron transport
			cellular component	endoplasmic reticulum
				membrane
			molecular function	heme binding
				iron ion binding
				metal ion binding
				monooxygenase activity
				oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
1.49271	down	Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]	biological process	cell cycle
				DNA repair
				ubiquitin cycle
			cellular component	cellular_component
			molecular function	molecular_function
				protein binding
1.49444	up	Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	biological process	protein modification process
				ubiquitin cycle
			molecular function	ligase activity
				small conjugating protein ligase activity
				ubiquitin-protein ligase activity
1.49558	down	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	biological process	BMP signaling pathway
				bone mineralization
				cardiac cell differentiation
				cartilage development
				cell fate commitment
				cell growth
				cell-cell signaling
				embryonic development
				epithelial to mesenchymal transition
				growth
				inflammatory response
				negative regulation of cell proliferation
				negative regulation of progression through cell cycle
				odontogenesis (sensu Vertebrata)
				organ morphogenesis
				osteoblast differentiation
				positive regulation of astrocyte differentiation
				positive regulation of ossification
				positive regulation of osteoblast differentiation
				regulation of transcription
				ureteric bud branching
			cellular component	extracellular region
				extracellular space
			molecular function	cytokine activity
				growth factor activity
				protein binding
				transforming growth factor beta receptor binding
1.49923		Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	biological process	blood vessel development

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.